Osteoinductive material | MDS coaching & Preparations B-IDS 09818001730, 08690014009

Which of the following is Osteoinductive material?
A. Decalcified Freeze Dried Bone
B. Hydroxyapatite
C. Tricalciumphosphate
D. Dura

Ans. (A)

Osteoinduction- Is a chemical process by which molecules contained in the graft (bone morphogenetic proteins) convert the neighbouring cells into osteoblasts, which in turn form the bone.

Decalcified Freeze Dried Bone Allograft- Experiments by Urist have established the osteogenic potential of DFDBA. Demineralization in cold,diluted hydrochloric acid exposes the components of bone matrix which are closely associated with collagen fibrils and have been termed bone morphogenetic proteins (BMPs).

Calcium Phosphate Biomaterials- These materials are osteoconductive, not osteoinductive, meaning that they will induce bone formation when placed next to viable bone but not when surrounded by non-bane-forming tissue such as skin. Two types of calcium phosphate ceramics have been used, as follows- Hydroxyapatite (HA)- Has a calcium-to- phosphate ratio of 1.67, similar to that found in bone materials. HA is generally nonbioresorbable. Tricalcium Phosphate (TCP)- With a calcium- to-phosphate ratio of 1.5, is mineralogically f3 Whitlockite. TCP is atleast partially bioresorbable.