Bismuth subsalicylate is used in the treatment of peptic ulcer primarily because of its ability to:
a. Neutralize gastric acidb. Eradicate Helicobacter pylori
c. Stimulate mucus secretion
d. Inhibit acid secretion
Ans. (B). Eradicate Helicobacter pylori
The gram-negative bacillus Helicobacter pylori is believed
to be a significant factor in the pathogenesis of duodenal ulcers. Ulcer
treatment includes bismuth salts because they eradicate this organism and are
effective in preventing ulcer recurrences. Bismuth preparations may also coat
the ulcer base, adsorb pepsin, and enhance prostaglandin synthesis.
Bismuth does not directly inhibit acid secretion or pepsin production and it is
not an antacid.
